Eventos adversos do metilfenidato oros em usuários com transtorno de déficit de atenção e hiperatividade: uma revisão integrativa da literatura

Abstract

Attention Deficit Hyperactivity Disorder (ADHD) is classified as a neurological disor-der that compromises one's development, presenting symptoms of inattention and / or hyperac-tivity / impulsivity. It affects children and adolescents more, and can continue into adulthood. The aim of the study was to investigate the adverse events that methylphenidate hydrochloride OROS causes in users of it. For this, an integrative review of the literature was done in the databases SCIELO, MEDLINE, PU-BMED, PUCHEM, THE CONCHRANE LIBRARY, SCI-ENC DIRECT, the language of the articles were Portuguese and English and the descriptors used were: methylphenidate OROS, ADHD, effects ADHD 'Attention Deficit Hyperactivity Dis-order', 'Methylphenidate / adverse effects', 'Methylphenidate / pharmacology'. Results: The sur-vey was conducted between August and the end of October 2018, resulting in a total of 2766 publications, three selections of articles were made, withdrawing articles that did not mention anything about the drug's adverse events: 266 articles in the first selection, 99 articles in the second selection and 29 articles were used in the study. Of these 29 articles used in the study, 10 articles are from the MEDLINE database which reported as common adverse events head-ache, dry mouth, anxiety, nausea, increased blood pressure, insomnia, increased heart rate, bruxism, irritability, weakness muscular, diarrhea, drowsiness; 6 articles are from the PUB-MED database: reversible elevation of liver enzymes, decreased appetite, decreased sexual desire, perspiration, biting mouth and tongue behavior, two reported cases of hypersexual be-havior in a 15-year-old an 8-year-old boy, a case of complex night bizarre hallucinations; 3 articles in the SCIELO database: insomnia or drowsiness, worsening of cognition, hyperten-sion, cardiac arrest, Zombie Like effect (absence of thoughts and sensations), decreased appe-tite, dry mouth, irritability, risk of worsening cardiovascular diseases and hypertension; 10 articles in the SCIENCE DIRECT database: common adverse events.